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Cholinergic Crisis

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Copious SecretionsBronchospasm riskReactive AirwayBradycardiaSkeletal Muscle WeaknessAvoid SuccinylcholineAvoid Muscarinic AgonistsAspirationDifficult AirwaySeizuresPostoperative Ventilation Likely

Pathophysiology

Cholinergic crisis is what follows when acetylcholinesterase is inhibited or inactivated, acetylcholine accumulates at the neuromuscular junction and synapses, and both nicotinic and muscarinic...

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