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Diphenhydramine (Benadryl)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Classification:
First-generation H1-antihistamine (ethanolamine), anticholinergic
Therapeutic Effects:
Antihistamine, antiemetic, sedative, anticholinergic, antipruritic, treatment of dystonic reactions
Primary Considerations:

Sedation additive - Potentiates opioids, benzodiazepines, and volatile agents; anticipate deeper sedation and slower emergence, especially in the elderly. Dystonia rescue - First-line for acute...

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