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Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

AnemiaHypoxiaAvoid HypoxiaCyanosisLocal Anesthetic SensitivityTachycardiaHypotensionDyspneaHemolysis RiskMethemoglobinemia

Pathophysiology

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-limiting first step of the pentose phosphate pathway, converting NADP to NADPH. NADPH keeps glutathione reduced, which is how the red cell...

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