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Graft-versus-Host Disease (GVHD)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

ImmunocompromiseSkin FragilityCareful PositioningDry EyesDry MouthDifficult AirwayDyspneaDehydrationUnstable ElectrolytesAnemiaSepsisHepatic DysfunctionIrradiated Blood ProductsThrombocytopenia

Pathophysiology

Graft-versus-host disease (GVHD) occurs when immunocompetent donor T lymphocytes in an allogeneic graft recognize recipient MHC/HLA as foreign and attack it - a type IV cytotoxic T-cell reaction...

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