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Methadone

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Classification:
Opioid agonist, NMDA receptor antagonist, serotonin/norepinephrine reuptake inhibitor
Therapeutic Effects:
Analgesia, opioid maintenance therapy, prevention of opioid withdrawal
Primary Considerations:

Dose-dependent duration — doses ≤10 mg produce 3–4 hours of analgesia (redistribution-limited); doses ≥20 mg leverage the long elimination half-life for ~35-hour effect. Opioid use disorder patients...

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