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Methadone Maintenance Use

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

ArrhythmiasBradycardiaRefractory PainWithdrawalOptimize ElectrolytesHypokalemiaHypomagnesemiaHypoglycemiaDelayed EmergenceOpioid ToleranceQT Prolongation

Pathophysiology

Methadone is a synthetic full mu-opioid agonist that is also a noncompetitive NMDA receptor antagonist. In maintenance treatment for opioid use disorder it is titrated to a daily dose that suppresses...

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