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Milrinone (Primacor)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Classification:
Phosphodiesterase-3 (PDE-3) inhibitor, inodilator, positive inotrope
Therapeutic Effects:
Positive inotropy, vasodilation (systemic and pulmonary), lusitropy (improved diastolic relaxation), reduction of pulmonary vascular resistance (PVR)
Primary Considerations:

Inotropy Without Tachycardia - Milrinone increases cardiac contractility and cardiac output without the beta-receptor stimulation that drives tachycardia with dobutamine or epinephrine . Good choice...

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