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Negative Pressure Pulmonary Edema (NPPE)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

HypoxiaAvoid HypoxiaCyanosisDyspneaCopious SecretionsDifficult AirwayEdemaAvoid HypoventilationLaryngospasm RiskPulmonary Edema

Pathophysiology

Negative pressure pulmonary edema (NPPE) is noncardiogenic pulmonary edema that follows forceful inspiratory effort against a closed upper airway — most often laryngospasm at extubation, with an...

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