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Opioid Withdrawal Syndrome

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

WithdrawalTachycardiaHypertensionDehydrationUnstable ElectrolytesHyperthermiaRefractory PainOptimize HydrationAutonomic Hyperactivity

Pathophysiology

Chronic mu stimulation suppresses endogenous endorphin production and drives adenylyl cyclase superactivation. Remove the exogenous opioid, by cessation or by giving a partial agonist or an...

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