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Thrombotic Thrombocytopenic Purpura (TTP)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

AnemiaArrhythmiasBlood Loss (Excessive)HypervolemiaImmunocompromiseRenal DysfunctionSeizuresSepsisStroke RiskAvoid NeuraxialHemolysis RiskPlatelet DysfunctionThrombocytopenia

Pathophysiology

TTP is a thrombotic microangiopathy caused by severe deficiency of ADAMTS13, the protease that cleaves ultra-large von Willebrand factor ( VWF ) multimers. Deficiency is congenital (ADAMTS13...

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